Cannabis Inhibits SARS-CoV-2 Replication in Human Lungs, Study SuggestsPosted by On


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With the SARS-CoV-2 virus causing almost 3 million deaths worldwide, researchers have been scrambling to learn more about the deadly COVID-19 disease that has threatened global public health and world economies.

A new study, published on preprint server bioRxiv last week, suggests that a cannabis plant compound inhibited infection with SARS-CoV-2 in human lung cells. 

According to the researchers at the University of Chicago in Illinois, cannabidiol (CBD), a chemical in the Cannabis sativa plant, also known as marijuana, and its metabolite 7-OH-CBD, blocked SARS-CoV-22 replication in lung epithelial cells. Epithelial cells are cells that come from body surfaces, such as the skin, blood vessels, urinary tract or organs.

The researchers also found that CBD appeared to inhibit viral gene expression and reverse many of the effects SARS-CoV-2 has on host gene transcription. CBD also appeared to bring about the expression of interferons, proteins released by cells, in response to the entry of viruses, that are supposed to inhibit virus replication. In addition, for those patients who had been taking CBD, the incidence of SARS-CoV-2 infection was up to an order of a magnitude lower than in patients who had not been taking CBD.

“This study highlights CBD, and its active metabolite, 7-OH-CBD, as potential preventative agents and therapeutic treatments for SARS-CoV-2 at early stages of infection,” lead author Marsha Rosner and her…

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Tech

Get short URL

With the SARS-CoV-2 virus causing almost 3 million deaths worldwide, researchers have been scrambling to learn more about the deadly COVID-19 disease that has threatened global public health and world economies.

A new study, published on preprint server bioRxiv last week, suggests that a cannabis plant compound inhibited infection with SARS-CoV-2 in human lung cells. 

According to the researchers at the University of Chicago in Illinois, cannabidiol (CBD), a chemical in the Cannabis sativa plant, also known as marijuana, and its metabolite 7-OH-CBD, blocked SARS-CoV-22 replication in lung epithelial cells. Epithelial cells are cells that come from body surfaces, such as the skin, blood vessels, urinary tract or organs.

The researchers also found that CBD appeared to inhibit viral gene expression and reverse many of the effects SARS-CoV-2 has on host gene transcription. CBD also appeared to bring about the expression of interferons, proteins released by cells, in response to the entry of viruses, that are supposed to inhibit virus replication. In addition, for those patients who had been taking CBD, the incidence of SARS-CoV-2 infection was up to an order of a magnitude lower than in patients who had not been taking CBD.

“This study highlights CBD, and its active metabolite, 7-OH-CBD, as potential preventative agents and therapeutic treatments for SARS-CoV-2 at early stages of infection,” lead author Marsha Rosner and her…



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