An experimental pill from a new class of drugs has demonstrated potential in treating cannabis use disorder in a small study.
Based on the findings published in Nature Medicine, the drug, called AEF-0117, reduced the perceived positive effects of cannabis by up to 38% in a double-blind randomized controlled phase 2a trial led by Columbia University researchers.
Cannabis use disorder, which affects an estimated 30% of marijuana users per the Centers for Disease Control and Prevention (CDC), is characterized by the inability to stop using marijuana despite significant disruptions to daily life.
Signs of cannabis use disorder in young people can include declining academic performance, changes in relationships and disengagement from previously enjoyed activities.
Currently, no drugs have been approved by the Food and Drug Administration (FDA) to treat this disorder possibly affecting millions of Americans, according to NBC News.
The lead author of the study, Meg Haney, expressed optimism about the preliminary findings, describing them as “very encouraging.” Haney, the director of the cannabis research laboratory at Columbia University, highlighted that AEF-0117 is one of the few medications tested to directly decrease the effects of cannabis, with the goal of helping individuals abstain from its use.
The trial involved 29 adult men and women diagnosed with cannabis use disorder, who were daily consumers of approximately 3 grams of marijuana, six days a week. The study examined two…