West Yorkshire Police have seized around 400 cannabis plants worth more than £100,000.
Officers found the plants at a three-floor cannabis farm inside an old commercial unit on Bradford Road, near Dewsbury town centre, on Sunday, August 2.
The force says the plants are “in various stages of growth” and are worth more than £100,000.
The raid was carried out after officers in Kirklees received reports of suspicious activity outside the farm.
Earlier this year (April 16), officers seized more than 1,300 plants when they carried out a raid at a nearby cannabis farm in Daisy Hill.
Sergeant Richard Cotton said: “Officers located a substantial cannabis factory on Bradford Road in Dewsbury on Sunday and we are continuing our enquiries this week.
“While a full calculation of the value of the cannabis seized is yet to be completed it will clearly be a six-figure sum given the number of plants officers found.
“We would ask anyone who has any information about the cultivation or supply of drugs in Dewsbury to contact the Dewsbury Neighbourhood Policing Team on 101 or the independent Crimestoppers charity anonymously on 0800 555 111.
“All information and intelligence is fully assessed and explored for investigative possibilities by officers.”