This microscope image of the brain region called the hippocampus shows the protein targeted by cannabis-derived CBD, GPR55 (red), and brain cells (blue) that send their extensions out to form the layers seen in the image. The interconnected nature of the hippocampus makes it a major site for the initiation and spread of seizures. Photo courtesy of Tsien et al/Cell Press
Feb. 13 (UPI) — Researchers in New York have revealed a new way in which cannabidiol, or CBD, reduces seizures in children who suffer from various treatment-resistant forms of epilepsy.
The new study, published Monday and conducted at NYU Grossman School of Medicine, found CBD blocks signals carried by a molecule called lysophosphatidylinositol, or LPI, which is believed to amplify nerve signals but is more pronounced with epilepsy.
While researchers confirmed earlier findings that CBD blocks LPI’s ability to amplify nerve signals in the brain’s hippocampus, they also discovered for the first time that LPI also weakens signals that counter seizures.
“The study also clarified, not just how CBD counters seizures, but more broadly how circuits are balanced in the brain,” said corresponding author Richard Tsien, chair of the Department of Physiology and Neuroscience at NYU Langone Health.
“Related imbalances are present in autism and schizophrenia, so the paper may have a broader impact,” Tsien added.
The new study examined rodent models to explore the mechanisms behind seizures….
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