Joburg Emergency Services said there may be more fatalities as a result of the blaze.
At least 14 people have died in a fire in the Johannesburg CBD.
Several other people have also been injured.
It is understood the blaze started in the early hours of Thursday morning at a five-storey structure in the city.
Johannesburg Emergency Management Services (EMS) spokesperson Robert Mulaudzi said several others were also injured in the blaze.
Watch the fire in the Joburg CBD
“The firefighters attended to the fire at a four-storey building in Johannesburg CBD corner Alberts and Delver Streets. Thirteen bodies have been confirmed dead on scene.
“There are also 42 people who were treated for smoke inhalation and various injuries and were transpored to various healthcare facilities in the City of Johannesburg for further medical care,” Mulaudzi said.
Mulaudzi said the cause of the fire is subject to investigations.
This is a devloping story
Meanwhile, Mulaudzi said there were no reports of any damages or injuries after an earthquake hit several areas on the West Rand including Johannesburg on Wednesday night.
“At this stage, we have not yet received any major incidents throughout the City of Johannesburg in our emergency call centre.
“However, we will remain on high overnight to make sure that we can be able to respond to any area…