There’s been a recent push in the U.S. to make naloxone -; a fast-acting opioid antidote -; available without a prescription. This medication has saved lives, but it’s less effective against powerful synthetic opioids, such as fentanyl. In an interesting twist, researchers are now looking to cannabidiol (CBD), a component of marijuana, as a possible alternative to the popular antidote. Today, a team reports compounds based on CBD that reduce fentanyl binding and boost the effects of naloxone.
The researchers will present their results at the spring meeting of the American Chemical Society (ACS). ACS Spring 2023 is a hybrid meeting being held virtually and in-person March 26–30, and features more than 10,000 presentations on a wide range of science topics.
Fentanyl-class compounds account for more than 80% of opioid overdose deaths, and these compounds aren’t going anywhere -; it’s just too much of an economic temptation for dealers. Given that naloxone is the only drug available to reverse overdoses, I think it makes sense to look at alternatives.”
Alex Straiker, Ph.D., the project’s co-principal investigator
A new option could take one of two forms, according to Michael VanNieuwenhze, Ph.D., the other co-principal investigator for the project.
“Ideally, we would like to discover a more potent replacement for naloxone,” VanNieuwenhze says. “However, finding something that works synergistically with it, reducing the amount needed to treat an…
